PB0051 - A Multicenter Cohort Study of COVID-19 Associated Venous Thromboembolism in Admitted Patients Followed Longitudinally 3-Months After Discharge

Sunday, July 10, 2022

6:30 PM – 7:30 PM

Location: Exhibition

Presentation Format: In-Person

Presenting Author(s)

Chipman Taylor Drury, MD, MSc, FRCPC

Clinical Instructor
University of British Columbia
Vancouver, British Columbia, Canada

Co-Author(s)

CL

Chieh Min Benjamin Lai

Fellow
Division of Hematology, Department of Medicine, University of British Columbia
Vancouver, British Columbia, Canada
GM

Gary Misselbrook

Fellow
Division of Critical Care Medicine, Department of Medicine, University of British Columbia
Vancouver, British Columbia, Canada
AA

Alaa Al Zaki

Clinical Instructor
Division of Hematology, Department of Medicine, University of British Columbia
Vancouver, British Columbia, Canada
GB

Gurjeet Bhangu

Medical Undergraduate
Faculty of Medicine, University of British Columbia
Vancouver, British Columbia, Canada
MC

Maeve Conroy

Resident
Department of Medicine, University of British Columbia
Vancouver, British Columbia, Canada
LE

Lauren Eadie

Medical Undergraduate
Faculty of Medicine, University of British Columbia
Vancouver, British Columbia, Canada
DK

Divjot Kumar

Fellow
Division of Respiratory Medicine, Department of Medicine, University of British Columbia
Vancouver, British Columbia, Canada
CL

Chris Li

Resident
Department of Medicine, University of British Columbia
Vancouver, British Columbia, Canada
DM

Domnick Manhas

Resident
Department of Medicine, University of British Columbia
Vancouver, British Columbia, Canada
NS

Navneet Singh

Medical Undergraduate
Faculty of Medicine, University of British Columbia
Vancouver, British Columbia, Canada
JY

Jack Hao Yuan

Medical Undergraduate
Faculty of Medicine, University of British Columbia
Vancouver, British Columbia, Canada
Agnes Y.Y. Lee

MD
University of British Columbia
Vancouver, British Columbia, Canada
TW

Tony Wan

Clinical Assistant Professor
Division of General Internal Medicine, Department of Medicine, University of British Columbia
Vancouver, British Columbia, Canada

Background: The incidence of venous thromboembolism (VTE) in patients with COVID-19 during hospitalization and in the post-discharge setting has been reported with wide variability. Many studies have short follow-up, reported the early phase of the pandemic, or did not report bleeding or anticoagulant dosing.

Aims: We determined the incidence of symptomatic VTE and bleeding in patients admitted to hospital for COVID-19 and their 3-month risk of VTE post-discharge.

Methods: All patients admitted for COVID-19 at 5 regional hospitals were identified between January 1 and December 31, 2020. Data were collected from their hospital admission and for a minimum of 3 months post-discharge. Re-admissions during this period were considered as post-discharge data of the index admission. Standard thromboprophylaxis for critical care and ward patients were enoxaparin 30 mg twice daily or 40 mg once daily. Post-discharge thromboprophylaxis was not given. Patient consent was waived by the institutional research ethics board.

Results: A total of 565 patients were included. Baseline demographics are reported in Table 1. Median length-of-stay was 9.0 days (range 5-131). 178 patients (31.5%) required critical care support and 79 patients (14%) died during index admission. 25 patients (4.4%) had VTE during hospitalization, of which 17 occurred within first two weeks and none occurred in those on therapeutic anticoagulation. There were no fatal bleeds. 5 patients (0.88%) developed critical site bleeding. Patient characteristics, anticoagulant use and bleeding rates during hospitalization are reported in Table 2. Among 486 discharged patients, median length of follow-up was 163 days (range 3-600): 63.5% had at least 90 days of follow-up data and 18.7% were lost to follow-up. 5 patients (1.3%) had symptomatic VTE diagnosed within 3 months after discharge.

Conclusion(s): The in-hospital incidence of VTE in COVID-19 was lower but post-discharge incidence was higher than other studies. Therapeutic anticoagulation appeared protective against symptomatic VTE.