PB0246 - Validation of Thai Pediatric Bleeding Assessment Tools Mobile Application for Diagnosis of Pediatric Bleeding Disorders

Background: Mild bleeding disorders such as von Willebrand disease (vWD) and other platelet disorders are usually underdiagnosed due to minor signs and symptoms. In 2017, the Thai-pediatric bleeding assessment tool (Thai-pediatric BAT) was translated and validated. It is now used for screening bleeding disorders. Its limitation is that the BAT is designed for medical personnel; therefore, it requires additional time during patients' visits. Mobile application for self-screening Thai-pediatric BAT may be useful for screening, especially in community.

Aims: To develop and validate self-screening mobile application for bleeding disorders in children.

Methods: After inform consent, Thai pediatric-BAT mobile application was firstly developed. Children with known bleeding disorders were interviewed using the paper-based BAT and mobile application at least two weeks apart. Pearson correlation coefficient was used for analysing relations between paper-based BAT and mobile application. The cut-off bleeding score of mobile application was calculated to predict bleeding disorders.

Results: After mobile application was developed by using simple sentences with additional video, pictures, and auto-calculation. The Thai pediatric-BAT mobile application showed a strong correlation with paper-based BAT. The correlation coefficient(r) is 0.956 (P < 0.001) in PBQ and 0.970 (P < 0.001) in ISTH scoring system. The score equal or more than three (≥3) was considered abnormal. The PBQ bleeding score ≥3 had a sensitivity of 90.9%, a specificity of 94.7%, a positive predictive value of 94.6% and a negative predictive value of 87% (P < 0.001). The ISTH bleeding score ≥3 had a sensitivity of 90.9%, a specificity 93.93%, a positive predictive value of 93.3% and a negative predictive value of 93.3% (p < 0.001).

Conclusion(s): Thai pediatric-BAT self-screening mobile application was proven to have a strong relation with the paper-based BAT version. Further study regarding the effectiveness of mobile application is warranted. Therefore, this application is a convenient and effective self-screening tool for increasing diagnosis of pediatric bleeding disorders.