VPB0024 - Some Hemostasis Parameters Concentrations in Coronary Artery Disease Patients depending on Arrhythmias

Sunday, July 10, 2022

6:30 PM – 7:30 PM

Location: Exhibition

Presentation Format: Virtual

Presenting Author(s)

YT

Yuliya V. Tyravska, PhD, MD

Assistant Professor
Bogomolets National Medical University
Kyiv, Kyyiv, Ukraine

Co-Author(s)

VL

Victor G. Lizogub

Professor
Bogomolets National Medical University
Kyiv, Kyyiv, Ukraine
OS

Olexiy M. Savchuk

Professor
Taras Shevchenko National University of Kyiv
Kyiv, Kyyiv, Ukraine

Background: Relationships between coronary artery disease (CAD) course and hemostasis indicators are well-established. However, the influence of arrhythmia on hemostasis in CAD patients is still under question.

Aims: To investigate concentrations of soluble fibrin monomer complex (SFMC), prothrombin pool (PP), serotonin and factor von Willebrand (vWF) in CAD patients depending on arrhythmias.

Methods: In our cross-sectional study, we recruited 102 CAD patients: 23 with stable angina (SA) (the median age 62.0 (58.5-69.0) years, 13 males (56.5%)) and 79 with progressive unstable angina (UA) (the median age 64.0 (55.5-70.0) years, 51 males (64.5%)). Arrhythmias (the quantity and quality of premature ventricular complexes, paroxysms of atrial fibrillation, supraventricular tachycardia) were analyzed. All patients passed over 24-hour ECG monitoring during the first day of hospitalization. Blood plasma samples were drawn before treatment onset. We determined vWF and PP concentrations by ELISA. For assessment of SFMC concentration, we used the colorimetric ortho-phenanthroline method. We analyzed the blood plasma serotonin content by the ion-exchange chromatography with further measurement of serotonin on a fluorescence spectrophotometer. We used SPSS, v.22.0, particularly the Chi-square test, Fisher’s exact test, Mann-Whitney test, Spearman test for comparison of parameters among the groups and establish the relationships between them.

Results: Arrhythmias were registered in 57 patients (72.2%) with UA and 11 patients (47.8%) with SA (F=0.043). Concentrations of observed hemostasis parameters are demonstrated in Table.
Significant differences were registered in SFMC and vWF concentrations in UA patients depending on arrhythmias presence (p=0.002, p=0.009, respectively), but not in PP (p=0.123) and serotonin concentrations (p=0.264) as well as observed parameters concentrations in SA patients with or without arrhythmias. Correlations were noticed between presence of arrhythmia in UA patients and SFMC concentration (r=0.454, p=0.001) as well as vWF (r=-0.376, p=0.008).

Conclusion(s): Arrhythmias in UA patients unlike SA patients are suggested to enhance the trends of thrombophilia. Further investigations are warranted.