VPB0121 - EVALUATION OF CLOT WAVEFORM PATTERNS IN CoVID-19 PATIENTS

Background: Recent evidence has suggested the presence of unique coagulation abnormalities in patients with COVID-19. Clot waveform analysis (CWA) has not been adequately described as a tool for the evaluation of coagulation.

Aims: To comparatively assess the changes in clot waveform analysis (CWA) parameters between COVID-19 patients upon hospital admission and healthy individuals.

Methods: In this retrospective observational study, we evaluated 227 CoVID-19 patients upon their hospital admission, prior to the initiation of anticoagulation therapy relative to 84 healthy individuals. Coagulation tests and CWA were performed on BCS® XP System (SIEMENS). The CWA parameters of PT, aPTT and Fifrinogen (FIB) were the change in Absorbance (dmA) and the time difference between the starting time of the reaction (mixing of reagent and sample) until a specific absorbance change (absorbance threshold). All statistical analyses were performed using SPSS27. Variables were tested with Student’s t tests or Mann–Whitney U tests for differences in distributions of dmA and dsec of PT, aPTT and FIB between two groups. P values < 0.05 were considered statistically significant.

Results: A statistically significant increase in the dmA values of PT, aPTT and FIB was detected in CoVID-19 patients compared with the healthy individuals (p < 0.001) (fig.1). A statistically significant decrease in CoVID-19 patients was found only for the dsec values of FIB (p < 0.001) (fig.2).

Conclusion(s): CWA variables upon admission in COVID-19 patients may be used for the evaluation of their inflammatory response or/and hypercoagulopathy. Our results may help to identify patients at a high risk of thromboembolism.