VPB0520 - Assessment of thrombogenesis activity after endovascular treatment of coronary arteries

Background: Vascular stenosis is usually accompanied by impaired rheological properties of blood, leading to thrombotic complications. The detection of early stenting can improve the outcomes of stenting.

Aims: The study included 50 patients (23 men, 27 women) aged 49-75, who were admitted for endovascular treatment. The investigations were performed dynamically: before stenting, 24 hours and 30 days after stenting. The parameters of global thrombodynamic test, platelet count, routine hemostasis indicatorswere assessed.

Methods: The study included 50 patients (23 men, 27 women) aged 49-75, who were admitted for endovascular treatment. The investigations were performed dynamically: before stenting, 24 hours and 30 days after stenting. The parameters of global thrombodynamic test, platelet count, routine hemostasis indicatorswere assessed.

Results: It was found that compared to the control group, the rate of fibrin clot growth was increased by 32% in the middle-aged group and by 38% in the elderly group (p < 0.05) in patients with coronary artery disease. The size of the clot after 30 minutes of follow-up was 19.2% higher than that of the control group in the middle-aged patients and 23% higher in the elderly patients (p < 0.05). The presence of spontaneous clots was detected in 10% of middle-aged patients and in 17.5% of elderly patients. 24 hours after the operation a hypercoagulable state was registered in 16% of patients. On the 30th day after the operation a hypercoagulable state was registered in 24% of patients

Conclusion(s): The obtained results allowed us to identify some patients at risk of thrombosis and restenosis. The use of new approaches in clinical and laboratory practice can improve the outcomes of stenting by early diagnosis of hemostasis disorders.