PB0026 - Decreased Levels of Factor VIII During Acute Ischemic Stroke Predict Excellent Outcome Thirty Days After

Sunday, July 10, 2022

6:30 PM – 7:30 PM

Location: Exhibition

Presentation Format: Virtual

Presenting Author(s)

Mohamed El Horri, Sr., PharmD , AssProf LabHaem

Head of Laboratory Haematology Unit
Regional Military University Hospital of Oran
Oran, Oran, Algeria

Co-Author(s)

FB

Farid Bemmoussat

Unit of Neurology
Regional Military University Hospital of Oran
Oran, Oran, Algeria
Messaoudi Reda, PHD

Head of day hospitalization
University Ahmed Benbella N°1 Oran
Oran, Oran, Algeria
Mm

Moueden mohamed amine

HEAD OF HEMOBIOLOGY
University Hospital Oran
Oran, Oran, Algeria
FE

Fatima El Horri

Department of Pediatrics
Mixed Hospital of Ras elma
Sidi Bel Abbes, Sidi Bel Abbes, Algeria
DB

Driss Benlaldj

Department of Laboratory Haematology and Blood Transfusion
University Hospital Center of Oran
Mostaghanem, Mostaganem, Algeria
IK

Ibrahim Khachaa

Head od Blood Bank Unit
Regional Military University Hospital of Oran
Oran, Oran, Algeria
GK

Ghizlene Latifa Khitri

Laboratory Haematology Unit
Regional Military University Hospital of Oran
Tlemcen, Tlemcen, Algeria
AC

Abdelkrim Chikh Khelifa

Laboratory Haematology Unit
Regional Military University Hospital of Oran
Saida, Saida, Algeria
MS

Mohamed Nadir Smahi

Department of Pneumology
Regional Military University Hospital of Oran
Oran, Oran, Algeria
KB

Khadidja Benbouhadi

Laboratory Haematology Unit
Regional Military University Hospital of Oran
Oran, Oran, Algeria
KK

Khalil Kebir

Laboratory Haematology Unit
Regional Military University Hospital of Oran
Oran, Oran, Algeria
SZ

Soufiane Zatir

Chief of Department of Emergency Medicine
Regional Military University Hospital of Oran
Oran, Oran, Algeria
LB

Lahcene Benmahdi

Chief of Department of Laboratory Medicine
Regional Military University Hospital of Oran
Oran, Oran, Algeria
BH

Brouk Hacene

Professor
Hemobiology and blood transfusion
Annaba, Annaba, Algeria

Background: Increased levels of factor VIII (FVIII) have been associated with acute ischemic stroke(AIS), but its prognostic value remain controversial until now. That’s why FVIII testing during AIS, seems to be interested and also, can be useful for assessing the chances of recovery which is critical to optimize poststroke care.

Aims: To assess the prognostic value of factor VIII in the prediction excellent outcome.

Methods: The study was carried out on 46 adult patients with acute ischemic stroke. Blood samples were taken on admission, to measure FVIII activity. Neurological deficit of patients was determined according to modified Rankin scale (mRS). The end point of this study was excellent outcome at 30 days defined as mRS: (0 –1), during the follow-up period.

Results: On the admission, elevated levels of FVIII, were associated with severity of AIS according to mRS: mean and IQR values: mRS < 5: 127% (73 – 148%); mRS ≥ 5: 193% (125 – 245%), p = 0.042.
Moreover, a positive moderate correlation was found between FVIII levels and mRS at 30 days of follow-up, with coefficient of Pearson (r = 0.600) and p < 0.0001. FVIII was significantly decreased in patients with excellent outcome (mRS: 0 – 1) comparing to the rest of patients, mean and IQR values: mRS ≤1: 98% (73 – 113%); mRS > 1: 171% (108 – 235%), p < 0.0001. Patients with factor VIII levels below 124% are more likely to have an excellent evolution30 days after AIS, with an Odds Ratio = 20 [CI: 3.72 – 107.65]; p < 0.0001; χ² = 15.97.

Conclusion(s): In patients with ischemic stroke, the decrease in factor VIII activity levels shows good prognosis value concording with excellent functional results at 30 days. These results may be useful both in clinical practice and in research but require validation by further studies.