VPB0691 - 10 Years Comparative Hemophilia Prophylaxis across São Paulo State - Brazil

Background: According to the World Federation of Hemophilia, Brazil has the 3rd largest population of hemophiliacs. Primary prophylaxis was implemented in Brazil from 2009 onwards.

Aims: To compare demographic and clinical Hemophilia A and B patients’ characteristics across São Paulo State.

Methods: São Paulo State Hemovida Web – Coagulopathies registry from 2009 to 2018 quantitative and temporal series analysis.

Results: The prophylaxis program started in 2009. In 10 years, 2045 Hemophilia A (HA) or B (HB) patients were followed and registered at hemophilia centers in São Paulo State. Patients registered increased an average 3.2% per year, and 2015 had the largest number of new patients. Hemovida registered patients are 82.4% HA and 17.6% HB. Age stratum 20 to 39 years had the highest hemophilia prevalence. Overall, 88.9% participated in the long-term primary or secondary prophylaxis program and 6% are only on-demand treatment. Of these, 3.7% registered patients developed immunotolerance. Standardized mortality rates were 2.94 amid the cohort anteceding the program mainly at the 30-39 age stratum and 1.24:1 000 among those currently under prophylaxis, mainly over 60 years.

Conclusion(s): In Brazilian São Paulo State, similar to other countries, HA and HB regular prophylaxis treatment schedule has been, gradually, personalized and decreased morbidity and mortality.