VPB0289 - -T cells predict the response of High-dose dexamethasone in pediatric newly dignosed immune thrombocytopenia

Sunday, July 10, 2022

6:30 PM – 7:30 PM

Location: Exhibition

Presentation Format: Virtual

Presenting Author(s)

Zhifa wang

Hematology Center, Beijing Children’s Hospital, Capital Medical University
Hematology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health
Beijing, Beijing, China (People's Republic)

Co-Author(s)

RW

Runhui Wu

Director and Physician in Chief
Beijing Children’s Hospital, Capital Medical University, Beijing, China
Beijing, Beijing, China (People's Republic)

Background: Immune thrombocytopenia (ITP) is a disease characterized by isolated thrombocytopenia. In our previous studies, we also found that High-dose dexamethasone(HDD) provides a high rate of remission as a frst-line treatment for children previously untreated primary ITP, with better tolerance than conventional PDN.

Aims: The present study aimed to explore the predictive value of -T cells on HDD sensitivity in patients with ITP and their effect on the pathogenesis of ITP.

Methods: We retrospectively analyzed the response of High-dose dexamethasone in pediatric newly dignosed immune thrombocytopenia from February 2018 to August 2021. The distribution of age, gender, and measured CBC parameters, including PLTs, white blood cells (WBCs), absolute lymphocyte count (ALC) and Hemoglobin (Hb) among the study were recomed and compared. Hematological indices including CD3+CD4+CD25+FOXP3+, CD4+, CD8+, CD4+/CD8+, αβ-T, γδ-T, DNT-T cells were measured and compared between the two groups.

Results: At 1 week, the children were divided into two groups based on their respond to HDD.There were no significant differences in the absolute number of CD3+, CD8+, CD8-, CD4+CD25+FOXP3+ ,CD4-CD8-, αβ-T, DNT T cells in BM between CR+R group and NR group (p > 0.05) . However, the absolute number of CD4+ , the CD4:CD8 ratio and the γδ-T cells was higher in the patents of CR +R group when compared the NR group (p < 0.05) .

Conclusion(s): This is the first study to report the association between the γδ-T cells in peripheral blood with the ITP patients. The CD4+/CD8+ rate and the γδ-T cells maybe the reliable factors for predicting the early response of HDD therapies.