VPB0113 - Evaluation of intravascular coagulation in patients with COVID-19 pneumonia.

Background: Several studies reported the frequent occurrence of Disseminated Intravascular Coagulation (DIC) in COVID-19 patients with acute respiratory distress syndrome (ARDS). The diagnosis of DIC by the validated ISTH DIC score, might be useful as readily assessable prognostic parameter.

Aims: The aim of our study was to explore DIC occurs and analyze the coagulation parameters of patients with COVID-19 pneumonia admitted to our hospital.

Methods: A retrospective analysis of hospital-based records of 62 COVID-19 patients with ARDS. Data including D-dimer, routine investigations (platelet count, prolonged prothrombin time, D-dimer, fibrinogen and NLR ratio). DIC scorings within three days of admission were collected. The study was conducted in a tertiary care center catering to population of west Algeria.

Results: A total of 62 hospitalized patients with COVID-19 ARDS were recruited in our study. Mean age of the subjects were 60.46 (29- 91) years, and 69.5% of the total patients were male. The coagulation parameters assessment demonstrated abnormal mean of PT (sec) 14.3 (11.1-41.6), normal mean platelettes count 256 G/L (34-768). However, mean D-dimer level 1185 (150-11000), fibrinogen level 5.02 g/l (2.1-8.56) and NLR 7.3 (0.5-19.9) were particularly elevated.
Mean ISTH DIC Score were 1.68 (0-5), One patients 1.6% withe DIC score 5 and confirmed DIC. 16 patients 25.8% withe DIC score 0.
Our studies showed a significant positif correlation betwen NLR, ISTH score DIC and fibrinogen level respectively P< 0. 0001 and p < 0.001.

Conclusion(s): the DIC might not only be a concomitant finding, but even a pathophysiological process contributing to circulatory and organ failure, in COVID-19 ARDS patients.