PB1412 - Inherited thrombophilia and non-O blood type associated with recurrent spontaneous abortion.

Tuesday, July 12, 2022

6:30 PM – 7:30 PM

Location: Exhibition

Presentation Format: Virtual

Co-Author(s)

LS

Luca Spiezia

Associate Professor
Department of Medicine, University of Padova, Italy
Padova, Veneto, Italy

Presenting Author(s)

Anna Poretto, MD

doctor
Padova university hospital
SALGAREDA, Veneto, Italy

Co-Author(s)

EB

Elisabetta Borella

doctor
Padova University Hospital
Padova, Veneto, Italy
GT

Giacomo Turatti

doctor
Padova University Hospital
Padova, Veneto, Italy
MM

Michelangelo Marobin

doctor
Padova University Hospital
Padova, Veneto, Italy
CS

Chiara Simion

Fellow
Padova University Hospital
Padova, Veneto, Italy
EC

Elena Campello

Assistant Professor
Department of Medicine, University of Padova, Italy
Padova, Veneto, Italy
DT

Daniela Tormene

MD, PhD
University of Padova
Padova, Veneto, Italy
Paolo Simioni, MD, PhD

Full Professor
Department of Medicine, Thrombotic and Haemorrhagic Diseases Unit, University of Padua Medical School, Padua (Italy)
Padua, Veneto, Italy

Background: Several studies evaluated the association between inherited thrombophilias (IT) and recurrent spontaneous abortion (RSA) without reaching definitive conclusions.

Aims: We assessed the prevalence of IT (antithrombin (AT), protein C (PC) and protein S (PS) deficiencies; factor V G1691A mutation (FV Leiden), prothrombin G20210A mutation and non-O blood type in a group of women with a history of RSA.

Methods: N. 255 unselected women with a history of RSA (i.e. ≥ 3 consecutively) were considered for enrollment between December 2011 and December 2019. A group of age-matched women, with at least one normal pregnancy and no history of adverse pregnancy outcomes acted as controls. All participants underwent screenings for IT and ABO genotyping.

Results: N. 223 (mean age 37 yrs, range 25-42 yrs) women were enrolled. The prevalence of obesity and non-O blood was significantly higher in cases than controls (p 0.01 and < 0.05, respectively). The odds ratio (OR) of RSA in women with vs. without IT was 2.10 (95% CI, 1.26 to 3.50). The OR of RSA in women with non-O vs. O blood type was 1.46 (95% CI, 1.01 to 2.13). We found concomitant IT and non-O in n. 29 (13%) cases and n. 16 (7%) controls, OR 2.62 (95% CI, 1.32 to 5.17).

Conclusion(s): IT and non-O blood type appear to be individually associated with a significantly higher risk of RSA, which is further increased in subjects carrying both. Larger studies are warranted to validate our findings.