assistant professor Altai State Medical University, Barnaul, Russia Barnaul, Altaisky krai, Russia
Background: Under the action of excessive stressors of different nature, hemostasis can respond by forming a state of thrombotic readiness.
Aims: The paper aims to assess the effect of a single intensive physical exercise of varying duration on the hemostasis system, microvasculature, and endothelium of rats.
Methods: The hemostasis system and microvasculature were investigated in 60 mature male Wistar white rats after a 4-hour and 8-hour physical exercise on a rat treadmill.
Results: It was found that a 4-hour exercise resulted in an increase in the aggregation function of platelets with a subsequent increase in their number and hypercoagulation against the decrease in plasma anticoagulant activity. An 8-hour exercise increased the negative changes identified before. Thus, there was an increase in soluble fibrin monomer complexes, a decrease in fibrinogen and platelets in the blood, a decrease in plasma anticoagulant and fibrinolytic activity, the development of endothelial dysfunction and congestive phenomena in the microcirculation area.
Conclusion(s): The increase in the duration of stress exposure training from 4 to 8 hours leads to an increase in the severity of signs of the thrombotic state of readiness.