VPB0107 - Hemostasis markers determining unfavorable outcome in covid-induced coagulopathy

Sunday, July 10, 2022

6:30 PM – 7:30 PM

Location: Exhibition

Presentation Format: Virtual

Presenting Author(s)

Inna Berger, Phd

PhD , Senior Researcher
Head of the Scientific Laboratory of Hemostasis Pathology
Tashkent, Toshkent, Uzbekistan

Co-Author(s)

AM

Aziza Makhmudova

MD
Republican Scientific and Practical Medical Center of Hematology (RSPMTSG) of the Ministry of Health of the Republic of Uzbekistan
Tashkent, Toshkent, Uzbekistan
MS

Maksuda Shamsutdinova

MD
Specialized multidisciplinary infectious diseases clinic for the treatment of coronavirus infection Zangiota 1
Tashkent, Toshkent, Uzbekistan
AA

Azoda Achilova

PhD
Republican Scientific and Practical Medical Center of Hematology (RSPMTSG) of the Ministry of Health of the Republic of Uzbekistan
Tashkent, Toshkent, Uzbekistan
OM

Onajon Madasheva

Researcher
Republican Scientific and Practical Medical Center of Hematology (RSPMTSG) of the Ministry of Health of the Republic of Uzbekistan
Tashkent, Toshkent, Uzbekistan

Background: We analyzed the laboratory parameters of 150 hospitalized patients with COVID-19 associated pneumonia with severe damage to the lung fields (more than 55%). All patients were admitted to the intensive care unit on admission due to the severity of their condition. Analysis of laboratory data was carried out on the first day after admission. Of the 150 patients with severe course, 26 deaths (17.3%) and 124 (82.6%) recovery were recorded.

Aims: The aim was to identify the most significant marker of hemostasis that determines the outcome of the disease

Methods: The study of hemostasis parameters was carried out on an ACL-TOP 350 coagulometer manufactured by Internetional Laboratory (USA), including indicators of D-dimer, antithrombin III, protein C, free protein S, and other HemosIL reagents (USA).

Results: In patients with a lethal outcome, compared with surviving patients, there were observed: more severe lymphopenia, higher levels of leukocyte and neutrophil counts, higher values of D-dimer concentration, PTI below 70%, and higher concentration values were recorded in biochemical studies blood urea and creatinine.
75% of patients had high levels of C reactive protein and D-dimer in almost 100% of the cases among the deceased. Disease severity was associated with more pronounced changes in laboratory parameters. One of the parameters of the cytokine storm was taken IL - 6, which in 35% of cases was more than 10 pg / ml in recovered patients and in 64.5% of cases with mortality.

Conclusion(s): Thus, it can be argued that the combined determination of the level of D-dimer and IL-6 has the highest predictive value in relation to the development of a severe form of COVID-19.