PO0008 - D-dimer in SARS-CoV-2 ! its importance in diagnosis and treatment.

Background: Coronavirus disease 2019 (COVID-19) is a deadly respiratory disease caused by severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2).This virus may predispose patients to venous thromboembolic [VTE] complications.
.Venous Thromboembolic Disease i.e. DVT and PE are distinct clinical entities but manifestation of the same disease. Pulmonary embolism is a complication of DVT. Coagulopathy include haemostatic abnormalities with increased levels of D-dimers. D-dimers are fibrinolytic products produced at the site of venous thrombosis

Aims: Our aim was to study the presence or absence of D-dimers in the blood of a patient with suspected Covid 19 diseases which could help in confirming or refuting the diagnosis.

Methods: Study done at tertiary hospital, Mumbai, India, 400 patients sample tested for D-Dimer, admitted with fever, RT-PCR positive and some also had other underlying clinical history..

By using STA-Liatest D-D plus kit analyzed quantitative on Stago Compact Max Instrument using latex enhanced immunoturbidimetric assay.

Results: N: 50 Normal [12.5 %] D- dimer normal .Covid test negative, all tested lab parameters normal.
N: 340 true positive [85 %] D-dimer positive. Covid positive patients
N: 08: false positive [2 %] D-Dimer False Positive .Patient Covid negative
N: 02 false negative [0.5 %]-D-Dimer false negative. Patient Covid positive
Sensitivity: 99.42 %, Specificity: 86.21 %

[ Normal Range of D-DIMER: < or =500 ng/mL ]

Conclusion(s): D-Dimer is increased in thrombotic events indicating fibrinolysis.. D-Dimer quantification with persistent elevation of D-Dimer gives clue of presence of DVT which can avail in diagnosing VTE
Key message:
.Early diagnosis and prompt treatment can prevent patients from critical complication of VTE disease
Chest CT to be considered in all patients suspected of having COVID-19 who have an indication for hospital admission Prophylactic-dose low-molecular-weight heparin to be initiated in all hospitalized patients with proven or suspected COVID-19 .