Assistant Tashkent Pediatric medical Institute Tashkent, Toshkent, Uzbekistan
Background: The most important indicators of the plasma and platelet components of the hemostasis system in pregnant women with preeclampsia are of great importance in assessing the development of the disease severity.
Aims: to determine the character of changes in platelet aggregation activity in pregnant women with preeclampsia.
Methods: We studied the platelet aggregation activity in 112 pregnant women with preeclampsia and in 50 women with a physiological course of pregnancy in the third trimester. An assessment was made of the total aggregation activity of platelets according to the types of aggregation curves.
Results: The increase in the intensity of aggregation in pregnant women with preeclampsia with ADP stimulation of 1·10-3 m was 16.1% and 7.9%, respectively; ADP 1·10-5 m - 15.1% and 10.6%; ADP 1·10-7 m - 62.3% and 62.2%; adrenaline - 27.4 and 30.3% (P < 0.01). The intensity of secondary platelet aggregation during stimulation with ADP 1·10-5 m and adrenaline was also significantly higher than in conditionally healthy women (P < 0.001). At the same time, the slope of the aggregation curve at the stage of secondary aggregation exceeded that in healthy pregnant women (by 5.8%, respectively) (P>0.05). These changes were combined with an increase in the adhesiveness index by 11% in pregnant women. When evaluating the aggregation curves in healthe pregnants, a slight decrease in the frequency of two-phase curves of platelet aggregation was revealed due to an increase in irreversible aggregation during stimulation with ADP 1·10-5m and adrenaline. An increase in platelet aggregation activity, along with hypoaggregation, took place during stimulation with ADP 1·10-7 m, while the number of two-phase irreversible aggregation increased.
Conclusion(s): To sum up, pregnant women with preeclampsia have signs of thrombocytopathy and coagulopathy of in combination with a changes in platelet aggregation activity of the blood.
