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Recorded Session
AIRWAYS PHYSIOLOGY, PATHOPHYSIOLOGY & AIRWAYS DEFENSE
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AIRWAYS PHYSIOLOGY, PATHOPHYSIOLOGY & AIRWAYS DEFENSE
AIRWAYS PHYSIOLOGY, PATHOPHYSIOLOGY & AIRWAYS DEFENSE
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(380) Neutrophil Extracellular Traps Disrupt Bronchial Epithelial Barrier Function: Alpha-1 Antitrypsin to the Rescue
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(381) Carbonic Anhydrase12 Knockout Mimics CF Cellular Phenotypes
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(382) Mechanisms of Cysteine-Mediated Polymerization and Secretion of Muc5ac and Muc5b
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(383) ELD607 Inhibits Excessive Proinflammatory Ca
2+
Signaling in CF Neutrophils
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(384) Impact of elexacaftor/tezacaftor/ivacaftor therapy on the pathological reprogramming of lung-recruited neutrophils conditioned by cystic fibrosis airway fluid
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(385) Mechanisms by which CFTR may influence SARS-CoV-2 infection
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(386) Myeloperoxidase activity and methionine oxidation products in bronchoalveolar lavage are associated with heightened risk of bronchiectasis in CF infants and toddlers
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(387) Pre-infection Knockdown of Muc5b Reduces Severity of Chronic
Pseudomonas aeruginosa
Infection in the CFTR-KO Rat
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(388) Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer
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(389) The toxicology of ELD607, a novel immunomodulator of inflammatory responses in CF lungs
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(390) Proof-of-concept of ionocytes’ CFTR content as a novel biomarker for cystic fibrosis
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(391) Lef-1 Induces FoxI1-Dependent Ionocyte Specification From Submucosal Gland Progenitors
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(392) A Dry Powder Aerosol Comprising a Small Molecule Prosthetic Ion-channel for Treatment of People with Cystic Fibrosis
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(393) Consequences of Chronic Hyperglycemia in Human Cystic Fibrosis Bronchial Epithelial Barrier Function
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(394) Development of a Programmable Automated Cell Culture System to Mimic Cystic Fibrosis-Related Diabetes Conditions In Vitro
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(395) Absence of Slc26a9 function results in neonatal mortality in mice due to pulmonary complications.
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(396) Lung Extracellular Matrix Remodeling in Human Cystic Fibrosis and Implications for Innate Immunity
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(397) Sinonasal epithelial functional and transcriptional responses to long-term highly effective CFTR corrector therapy
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(398) The role of carbonic anhydrase in pathogen susceptibility in cystic fibrosis
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(399) Dynamic Regulation of ASL pH by TMEM16A in Nasal Epithelia Derived from CF Donors with Rare Class I Mutations.
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(400) A novel SLC26A9-inhibitor reveals SLC26A9 as not the constitutive airway chloride conductance
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(401) Neutrophil Elastase Increases Intracellular Calpain Activity and Calcium in CF and non-CF Macrophages
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(402) Inhibiting the neurogenic component of the response to hypertonic saline treatment increases mucociliary clearance in CF swine
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(403) Trikafta® modulator therapy reduces
Burkholderia cenocepacia
burden in an
in vitro
airway infection model
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(404) Why are mucins so gigantic and is it rational to sever them to aid mucus clearance?
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(405) Neutrophil Defect and Pathogen Selection in Cystic Fibrosis
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(406) Pulmonary ionocytes play a role in pH regulation in human airway epithelia
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(407) MUC-031 as novel mucolytic agent for the treatment of cystic fibrosis
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(408) Neutrophil Extracellular Traps (NETs) Must Spread and Overlap to Adversely Affect Mucus Rheology.
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(409) Neutrophil elastase (NE) mediated degradation of histone deacetylases in macrophages promotes High Mobility Group Box1 export from nucleus to cytosol.
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(410) Hypoxia-induced CFTR dysfunction is a universal mechanism underlying reduced mucociliary transport in sinusitis
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(411) Insulin-like growth factor binding protein (IGFBP-6) as a novel regulator of inflammatory response in Cystic Fibrosis airway cells
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(412) Novel Approaches to Identifying Ion Transport Dysfunction During the Nasal Potential Difference Assay
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(413) Patient-derived lung airway model to study CFTR function
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(414) Longitudinal analysis of early life bronchoalveolar fluid identifies immune mediators associated with bronchiectasis risk in children with CF
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(415) Bacteriophages that Treat
Pseudomonas aeruginosa
Infections Induce Pro-Inflammatory Immune Responses in the CF Airway Epithelium
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(416) Smooth muscle-specific CFTR loss induces airway hyperreactivity in response to TGFβ
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(418) Ablation of two distinct PDE4 subtypes produces diametrical (diametrically opposite) effects in an acute model of
Pseudomonas aeruginosa-
induced lung injury in mice
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(419) The Role of Macrophage CFTR in Lung Inflammation
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(420) Microtubule dysfunction as a mechanism of CF inflammation
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(421) Sonic Hedgehog Signaling Is Required for Basal Cell Specification of Pulmonary Ionocytes and Ciliated Cells in Human and Ferret Airways
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(422) Specific respiratory conductance by forced oscillations to reveal ventilation inhomogeneity in patients with cystic fibrosis
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(423) A novel method for isolation of small airway epithelial cells by bulk enzymatic digestion
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(424) Systems Serology in Cystic Fibrosis: Anti-
Pseudomonas
IgG1 Responses and Reduced Lung Function
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(425) Development of an AICDA-Cre
ERT2
Ferret Model to Study Adaptive Humoral Immunity
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(426) Metformin improves HMGB1-induced mucociliary dysfunction in CF airway epithelial cells
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(427) Persistence of cell type-specific transcriptomic changes in the nasal epithelium in people with cystic fibrosis receiving CFTR modulators
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(428)
Pseudomonas aeruginosa
lung infection in cystic fibrosis rats
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(429) Myeloperoxidase in extracellular vesicles isolated from airways of children with cystic fibrosis
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(430) Ivacaftor treatment decreases the prevalence of insoluble mucus flakes in young patients with CF
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(431) Lung infection in a chronic cystic fibrosis-related diabetes murine model
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(432) Molecular Signatures of Human Neutrophils from Healthy Subjects and CF Patients
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(433) Differential small RNA expression analysis reveals TGF-
β
role in SARS-CoV-2 infection of the CF airway
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(434) In vitro evaluation of TAVT-135, an artificial pan-genotypic chloride ion transporter
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(435) Wnt and TGFβ Signaling Imbalance in Cystic Fibrosis Airway Epithelium Polarization
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(436) Characterizing Lactate as a Key Metabolite in the Cystic Fibrosis Lung Environment
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(437) Sox9 and Lef1 regulate the fate and behavior of airway glandular stem cells in response to injury
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(438) Krt14 and Krt15 Influence Airway Basal Cell Proliferative Capacity and Fate
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(439) CFTR impairment strongly decrease SARS-CoV-2 replication in human bronchial epithelial cells
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(440) Novel mechanism of TGF-β1 signaling in human bronchial epithelia
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(442) CFTR Regulation of Naïve CD4+ T Cell Activity: Implications for Th2 Disease in Cystic Fibrosis
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(443) Elexacaftor/Tezacaftor/Ivacaftor treatment promotes inflammation resolution in people with CF
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(444) Elexacaftor/Tezacaftor/Ivacaftor Treatment Reduces Airway Inflammation in Cystic Fibrosis
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(446) Metabolites in Early Life Bronchoalveolar Fluid Associate With Future Bronchiectasis Risk in Children With Cystic Fibrosis
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(447) Mucociliary Interactions and the Vertical Clearance Assay 2.0
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(448) Pathological autoimmune responses in CF exacerbation
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(449) Pathways Balancing Basal Mucin and CFTR-mediated Fluid Secretion in the Human Small Airway
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(450) Pro-inflammatory Orai1 activity is elevated in CF patients regardless of Trikafta treatment
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(451) Robust and Efficient Workflow to Establish, Culture, and Functionally Assess Primary-Isolated Airway Epithelial Cells
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(452) Synergistic Mucociliary Clearance by β-adrenergic + Cholinergic Agonists Involves ENaC Inhibition and Bicarbonate Secretion
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(453) VDP comparison between spiral with post-acquisition denoising and cartesian acquisition for 19F lung MRI
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