Cedars Sinai Medical Center
Kavisha Arora, PhD
Research Scientist I/Instructor
Cedars Sinai Medical Center
As part of my graduate and post-doctoral studies, I identified macromolecular protein complexes of plasma membrane transporters CFTR (a chloride/bicarbonate transporter), MRP4 (a cyclic nucleotide efflux transporter), adenylate cyclase 6, and guanylate cyclase 2C of physiological significance and clinical implications to CFTR-related disorders including cystic fibrosis (CF), cholera, inflammatory bowel disorders and airway mucociliary clearance. These findings have resulted in publication in high impact journals such as ‘American Journal of Pathology’, ‘J. Biol. Chem.’, ‘Biochemistry’, ‘Blue journal’ (AJRCCM), ‘JCI Insight’ etc with several appearing as cover page study or having editorial commentary. While a graduate student at University of Tennessee Health Science Center (UTHSC) in Memphis, I studied macromolecular complexes of CFTR and their relevance to CF and IBD. I was awarded the prestigious Paul J. Quigley Scholarship and Gerwin Fellowship at UTHSC for excellence in graduate research work. During my postdoctoral training, I obtained funding from Cystic Fibrosis Foundation to support my study on rare mutations in Cystic Fibrosis (CF) and develop personalized medicine in CF. I have been awarded with Gilead research scholarship for CF research to continue my study on finding novel mechanisms of mutant CFTR correction in CF. My research interests include (i) identifying mechanisms of airway mucociliary clearance in CF. (ii) develop personalized medicine tools for CF therapy (ii) identifying protein-protein interactions relevant to correction of mutant CFTR in CF, and (ii) understanding the role of signaling pathways such as autophagy in CFTR-related disorders.
Thursday, November 3, 2022
9:45 AM – 11:45 AM ET