Newcastle University
Following PhD completion as an MRC Fellow with Kevin Docherty exploring gene and cell replacement therapy for diabetes, a Glaxo-Smith-Kline Senior Fellowship enabled Dr James Shaw to move to Newcastle University where he is Professor of Regenerative Medicine for Diabetes.
In addition to setting up a translational research laboratory he developed a regional complex type 1 diabetes service focused on specialist hypoglycaemia management incorporating pump therapy and continuous glucose monitoring. He has established a supra-regional islet transplant service truly integrated with the solid organ pancreas transplant programme.
He led the multicentre HypoCOMPaSS RCT in people with type 1 diabetes complicated by impaired awareness of hypoglycaemia and the UK Islet Transplant Consortium bid for dedicated NHS funding as standard of care in 2008. This underpinned a Diabetes UK grant to prospectively evaluate biomedical / psychosocial outcomes in all UK islet recipients; and enabled participation in the only international RCT in islet transplantation, evaluating the potential of a novel anti-inflammatory agent to maximise engrafted islet mass post-transplantation. He is clinical lead for an exercise in type 1 diabetes research programme in collaboration with Dr Dan West.
His laboratory group is exploring mechanisms underlying loss of beta-cell functional mass in diabetes in addition to innovations in islet transplantation. He is Newcastle lead for an MRC-funded initiative to extend the Quality and Safety in Organ Donation Biobank to include pancreas, islets, hearts and lungs, providing a unique platform for molecular phenotyping linked to clinical data and a circulating biomarker proteomic core.
He is clinical lead for the Newcastle University Regenerative Medicine, Stem Cells and Transplantation Theme and chairs the Northern Alliance Advanced Therapies Treatment Centre Clinical Advisory Group.
He co-edited the international textbook ‘Islet transplantation and beta-cell replacement therapy’ and is type 1 diabetes editor for the Oxford Textbook of Endocrinology and Diabetes.
Thursday, November 3, 2022
9:45 AM – 11:45 AM ET