assistant professor
Emory University
Name: Guiying Cui
Address: Department of Pediatrics
Division of Pulmonary, Allergy/Immunology, Cystic Fibrosis & Sleep
Emory - Children’s Center, Room 335B
2015 Uppergate Drive
Atlanta, Georgia 30322
E-mail Address: gcui2@emory.edu
Telephone: Office: 404-727-7352
Lab: 404-727-3461
Fax: 404-712-0920
Citizenship: USA citizen
Postgraduate Training and career:
1997-2001 Lecturer, Department of Physiology, China Medical University, Shenyang, P.R. China
2001-2005 Postdoctoral Fellow, School of Biology, Georgia Institute of Technology, Atlanta, GA
2006-2007 Postdoctoral Fellow, Department of Pharmacology, Emory University, Atlanta, GA
01/2008-09/2015 Instructor, Department of Pediatrics, Division of Pulmonary, Allergy/Immunology, Cystic Fibrosis & Sleep, Emory School of Medicine
09/2015-present Assistant professor, Department of Pediatrics, Division of Pulmonary, Allergy/Immunology, Cystic Fibrosis & Sleep, Emory School of Medicine
Bibliography:
1. Li JM, Cui G, Liu DJ, Cui H, Chang TH, Wang YP, Zhang KY. Effects of N-methyl berbamine on delayed outward potassium current in isolated rat hepatocytes. Acta Pharmacologica Sinica, 1998; 19 (1): 24 -26
2. Cui G, Li JM, Liu DJ, Cui H. Effects of noradrenaline on delayed outward potassium current in isolated rat hepatocytes. Acta Physiologica Sinica, 1998; 50 (2): 232-236
3. Cui G, Li JM, Cui H, Hao LY, Liu DJ, Zhang KY. Effects of calcium channel blockers on calcium release- activated calcium currents in rat hepatocytes. Acta Pharmacologica Sinica, 1999; 20 (5): 415- 418
4. Cui G, Tang H, Wu YH. Outward potassium currents in outer hair cells isolated from the cochlear of the guinea pig. Chinese Journal of Applied Physiology, 2001, 17 (1): 99-100
5. Cui G, Tang H, Wu YH,Li YX, Cui C. Attenuation of streptomycin ototoxicity by ATP. Journal of Clinical Otorhinolarygology, 2001; 15 (sup): 100 –101
6. Cui G, Tang H, Wu YH. Changes of K+ channels of outer hair cells in guinea pig cochlear with streptomycin. Chinese Journal of Pathophysiology; 2002; 18(6): 619-621
7. Cui G, Tang H, Cao Y, Wu YH. The PKA mechanism of increasing K+ currents of outer hair cells by TMP. Chinese Pharmacological Buletin, 2002; 18 (6): 711-712
8. Wang YX, Cui G, Shen J, Huang AJ, Liu XY, Chen YZ, Jiang CL. Analgesic domains of interferon -. Neuroreport, 2001, 12 (4): 857-859
9. Fuller MD, Zhang ZR, Cui G, Kubanek J, McCarty NA. Inhibition of CFTR channels by a peptide toxin of scorpion venom. Am J
Physiol Cell, 2004, 287: C1328-1341. (PMID: 15240343)
10. Zhang ZR, Cui G, Zeltwanger S, McCarty NA. Time-dependent interactions of glibenclamide with CFTR: Kinetically complex
block of macroscopic currents. J Membr Biol, 2004, 201:139-155. (PMID: 15711774).
11. Zhang ZR, Cui G, Liu XH, Song BL, Dawson DC, McCarty NA. Determination of the Functional unit of the Cystic Fibrosis
Transmembrane Conductance Regulatior Chloride channel. J Biol Chem, 2005, 280(1): 458-468. (PMID: 15504728)
12. Matthew DW, Zhang ZR, Cui G, McCarty NA. The block of CFTR by Scorpion Venom is state dependent. Biophys J,
2005, 89(6): 3960-75 (PMC1366962)
13. Yu K, Xiao Q, Cui G, Lee A, Hartzell HC. The best disease-linked Cl- channel hBest1 regulates CaV1 (L-type) Ca2+ channels via src-homology-binding domains. J Neurosci. 2008, 28(22):5660-70 (PMC2587081)
14. Cui G, Zhang ZR, O’Brien AR, Song B, McCarty NA. Mutations at Arginine 352 Alter the Pore Architecture of CFTR. J Membr
Biol 2008, 222(2):91-106 (PMC2474774)
15. Lee A, Jimenez A, Cui G, Haeseleer F. Phosphorylation of the Ca2+-binding protein CaBP4 by protein kinase C zeta in
photoreceptors. J Neurosci 2007, 27(46):12743-54 (PMC2703458)
16. Cui G, Meyer AC, Calin-Jageman I, Neef J, Haeseleer F, Moser T, Lee A. Ca2+-binding proteins tune Ca2+-feedback to Cav1.3 channels in mouse auditory hair cells. J Physiol 2007, 585:791-803 (PMC2375505)
17. Jordan IK, Kota K, Thompson CH, Cui G, and McCarty NA. Evolutionary and functional divergence between CFTR and related ABC transporters. Proc Nat. Acad Sci USA, 2008, 105: 18865-70 (PMC2585040)
18. Cui G, Song BL, Turki HW, McCarty NA. Differential contribution of TM6 and TM12 to the pore of CFTR identified by three sulphonylurea-based blockers. Pflugers Arch, 2012, 463: 405-18 (PMID 22160394)
19. Cui G, Freeman C, Knotts T, Kuang C, Prince C, and McCarty NA. Two salt bridges differentially contribute to the maintenance of CFTR channel function. J Biol Chem, 2013, 288: 20758-67 (PMC3711338)
20. Rahman KS, Cui G, Harvey SC, McCarty NA. Modeling the conformational changes underlying channel opening in CFTR. PLoS One, 2013, 8:e74574 (PMC3785483)
21. Cui G, Kuang C, Rahman KS, Prince CZ, and McCarty NA. Three charged amino acids in the outer vestibule of CFTR stabilize
the open pore architecture. J Gen Physiol, 2014, 144:159-79 (PMC4113900)
22. Cui G, and McCarty NA. Murine and human CFTR exhibit different sensitivities to CFTR potentiators. Am J Physiol Lung Cell
Mol Physiol. 2015, 309: L687-99 (PMID: 26209275)
23. Infield DT, Cui G, Kuang C, McCarty NA. The positioning of extracellular loop1 affects pore gating of the cystic fibrosis
transmembrane conductance regulator. Am J Physiol Lung Cell Mol Physiol, 2015,310 (5):L403-14 (PMID: 26684250)
24. Cui G, Khazanov N, Stauffer BB, Infield DT, Imhoff BR, Senderowitz H, and McCarty NA. Potentiators exert distinct effects on
human, murine, and Xenopus CFTR. Am J Physiol Lung Cell Mol Physiol, 2016, 311(2):L192-207 (PMID: 27288484)
25. Stauffer BB, Cui G, Infield DT, and McCarty NA. Bacterial Sphingomyelinase is a state-dependent inhibitors of CFTR. Scientific
Report, 2017, 7:2931. (PMID:28592822)
26. Strickland K, Gorman Stock, Cui G, et al. ATP-dependent signaling in simulations of a revised model of Cytstic Fibrosis
Transmembrane Conductance Regulator (CFTR). J Phys Chem B, 2019: 123(15):3177-3188 (Co-first author). (PMID: 30921517)
27. Cui G, Stauffer BB, Imhoff BR, and McCarty NA. VX-770 potentiation of numerous human CFTR disease mutants influenced by
CFTR phosphorylation level. Scientific Report, 2019, 9 (1): 13460. (PMID:31530897)
28. Cui G, Hong J, and Chung-Davidson Yu-Wen et al. 2019. An Ancient CFTR ortholog informs molecular evolution in ABC
transporters. Dev Cell, pii: S1534-5807 (19)30773-7. (PMID:31679858)
29. Cui G, Cottrill K, et al. Alteration of membrane Cholesterol content plays a key role in regulation of CFTR channel activity.
Frontier Physiology, 2021, 12:652513. (PMID:34163370. PMCID: PMC8215275. DOI:10.3389/fphys.2021.652513)