S11--Delivery to the Lung: The Right Technology, the Right Cell

Thursday, November 3, 2022

3:30 PM – 5:30 PM ET

Location:108 AB

Chair(s)

Anjaparavanda P. Naren, BSc, MSc, PhD

Pulmonary Medicine
Cedars-Sinai Medical Center
Ruobing (Ruby) Wang, MD

Boston Children's Hospital

Initiatives to address CF genetic repair require advanced knowledge of the cellular targets most relevant to clinical benefit. As case in point, CFTR is highly expressed in pulmonary ionocytes. However, little is known about the physiological or functional significance of ionocyte biology to normal lung tissue, or the importance of CFTR rescue for mitigating CF lung disease. This symposium is designed to consider respiratory cell types that must be genetically corrected in order to benefit CF lungs. Presentations directed towards ionocyte biology, CF submucosal glands, basal cells, etc. will be discussed. The session will review the role and potential impact of these and other cell types as targets for CF intervention

Educational Objectives:

Defining CFTR expressing epithelial cell population within the airways, with special emphasis to understanding the physiology of the Ionocytes.
CF dependent differences in pulmonary epithelial cell transitions and their physiological and pathophysiological consequences.
Ideal candidate cell type to be targeted for therapeutic targeting of CFTR expression and function.

Presentations:

3:30 PM – 5:30 PM ET

S11.1 - The airway epithelial hierarchy
Speaker: Jayaraj Rajagopal, MD – MGH/HMS
3:30 PM – 5:30 PM ET

S11.2 - Defining Cellular Functions of the Pulmonary Ionocyte Using Genetic Ferret Models
Speaker: John F. Engelhardt, PhD – The University of Iowa
3:30 PM – 5:30 PM ET

S11.3 - The quest for granularity in airway ion transport
Speaker: John W. Hanrahan – Dep. Physiology, McGill Univ., Montréal, QC, Canada; RI-MUHC, Montréal, QC, Canada
3:30 PM – 5:30 PM ET

S11.4 - Targeting the CF airway for gene therapy
Speaker: Brigitte Gomperts – UCLA
3:30 PM – 5:30 PM ET

S11.5 - De novo generation of pulmonary ionocytes from induced pluripotent stem cells
Speaker: Ruobing (Ruby) Wang, MD – Boston Children's Hospital