S16--Contribution of CFTR to Innate Airway Defense

Chair(s)

• 

  Alix Ashare, MD, PhD

  Internal Medicine
  Dartmouth-Hitchcock Medical Center
• 

  Andrea Hahn, MD, MS

  Infectious Diseases
  Children's National Hospital

As innovations in cystic fibrosis (CF) therapies expand and CF transmembrane conductance regulator (CFTR) modulator therapy becomes more routinely used in clinical practice, the contribution of CFTR function to innate airway defense has taken on a renewed importance. This session will cover the expression and function of CFTR in different airway epithelium cells and airway macrophages. The speakers will also discuss the role of endoplasmic reticulum stress on airway epithelium inflammatory responses and how airway infection and inflammation can alter the efficacy of CFTR modulation.

Presentations:

• 9:45 AM – 11:45 AM ET

  S16.1 - Expression and Function of CFTR in Different Cells of the Airway Epithelium
  

  Speaker: John W. Hanrahan – Dep. Physiology, McGill Univ., Montréal, QC, Canada; RI-MUHC, Montréal, QC, Canada
• 9:45 AM – 11:45 AM ET

  S16.2 - The Role of ER Stress on CF Airway Epithelial Inflammatory Responses
  

  Speaker: Carla M. Ribeiro – Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
• 9:45 AM – 11:45 AM ET

  S16.3 - CFTR Dependent Changes in Macrophage Function
  

  Speaker: Benjamin T. Kopp, MD, MPH – Emory University
• 9:45 AM – 11:45 AM ET

  S16.4 - The Impact of Airway Infection and Inflammation on the Efficacy of CFTR modulation
  

  Speaker: Martina Gentzsch, PhD – University of North Carolina