Mayo Clinic
Jacksonville, United States
Natanael Zarco is currently Postdoctoral Research Fellow at the Neurogenesis and Brain Tumors Laboratory under the leadership of Dr. Hugo Guerrero-Cazares. He earned his M.Sc. and Ph.D. in Cellular and Molecular Neurobiology at CINVESTAV, Mexico. During that time, he developed research focus on Gene Therapy in Tumors of the Central Nervous System, mainly Glioblastoma. His work lead to understand how the therapeutic gene GAS1 induces the apoptosis of cancer cells. The last two years, he started to study the interplay between Glioblastoma (GBM) and the Ventricular-Subventricular Zone (V-SVZ) neurogenic niche trough different approaches. Currently he is studying the molecular mechanism by which Brain Tumor Stem Cells-derived Extracellular Vesicles (BTSCs-EVs) modulate the microenvironment close to the V-SVZ and their role on the phenotypic transformation of Neural Stem Cells. Natanael has an advanced knowledge on neurosciences, cell cycle, cellular quiescence, apoptosis, molecular biology of cancer, and gene therapy. His final goal is to impact the care of patients with brain cancers.