University Clinic of Freiburg
Freiburg, Germany
Dr. Vidhya Madapusi Ravi
Department of Neurosurgery,
University Clinic of Freiburg,
79108,
Baden Wurtemburg, Germany
Dr. Vidhya M. Ravi obtained her Ph.D. in Biophysics and Biochemistry from University Autonoma of Barcelona, Spain in 2016, where her thesis research was funded by European Union (FI-DGR AGAUR). Her long-term passion in the field of Neuroscience motivated her to University of Freiburg to conduct her postdoctoral research. She joined the lab of Prof. Dr. Ulrich G. Hofmann, where she established a 3D culturing method for the long-term preservation of adult human cortical brain tissue, considered to be a real challenge. She then moved to the Department of Neurosurgery, mentored by Prof. Dr. Jürgen Beck and Prof. Oliver Schnell, where she established a novel (3D human brain tumor) model to determine the distinct role of specific cell types in brain and their role in tumor progression. She further went on to define the mechanism of immune deactivation in GBM. Her latest work involves deep profiling of human GBM using spatially resolved RNA sequencing, proteomics and metabolomics. Dr. Ravi also has received several awards in her career including National scholarship in India, like DBT and ICMR junior research fellowship. Dr. Ravi’s long-term goals involve the generation of models of human disease as a platform to minimize the usage of animals in neuroscience research.
Selected Publications:
1. Heiland D.H*, Ravi V.M. *, et al. “Tumor Associated Astrocytes aid the evolution of immunosuppressive environment in Glioblastoma”. https://www.nature.com/articles/s41467-019-10493-6 (2019)
2. Ravi. V.M *, Joseph K * et al., “Human Organotypic Brain Slice Culture: A novel framework for environmental research in NeuroOncology” https://www.life-science-alliance.org/content/2/4/e201900305 (2019)
3. M.Schneider, L.Vollmer, A-L.Pothoff, V.M.Ravi et al., Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma https://academic.oup.com/neuro-oncology/advance-article-abstract/doi/10.1093/neuonc/noab092/6231712?redirectedFrom=fulltext (2021)