University of California, San Francisco
I am a physician-scientist devoted to improving therapies for patients with brain tumors. I am rigorously trained in quantitative biology and basic science research, with emphasis on applying functional genomics to brain tumor biology and therapeutics discovery. I have a track record of advancing knowledge in stem cell systems biology (Thomson, Liu et al. 2011 Cell), cerebral cortex brain development at single cell resolution (Liu et al. 2016 Genome Biol), non-coding functional genomics in cancer (Liu et al. 2017 Science; Liu et al. 2021 Nature Reviews Cancer; Liu et al. 2021 Methods Mol Biol), and neuro-radiation oncology (Liu et al. 2020, Genome Biol; Kline, Liu et al. 2018 J Neuro-Oncol). In particular, I am passionate about the intersection of quantitative biology and genomics, and applying these to the treatment of cancer. During my PhD, I co-developed a functional genomics platform harnessing engineered CRISPR/Cas9 systems to comprehensively define long non-coding genes that function in cancer cell maintenance (Liu et al. 2017 Science). I then advanced these findings to discover novel sensitizers of radiotherapy in adult and pediatric high grade glioma that can be therapeutically targeted using antisense oligonucleotides (Liu et al. 2020, Genome Biol). Currently I am a Chief Resident Physician and Holman Pathway Research Fellow in Radiation Oncology at UCSF