University of Michigan
Ann Arbor, United States
Dr. Haase started studying pediatric gliomas afteri joining the Castro-Lowenstein lab at the University of Michigan in 2017. Santiago’s work focuses on an understudied molecular subtype of pediatric high-grade gliomas, which harbors mutations on a histone gene (G34R/V mutations). The findings of this project led to the identification of molecular vulnerabilities in these tumors, which led to the discovery a link between DNA damage defects, genetic instability, and the immune response, and the work proved the potential of DNA damage response targeted therapies to treat G34-mutant gliomas.