University of Leeds & Department of Neurosurgery, Leeds Teaching Hospitals NHS Trust
Leeds, United Kingdom
Dr Ryan Mathew MD PhD PGDipClinEd FRCS(NeuroSurg) is an Associate Professor at the University of Leeds and an Honorary Consultant Neurosurgeon at Leeds Teaching Hospitals. He obtained an MBCHB with Honours and an intercalated BSc with Honours, the latter in Clinical Sciences (Tissue Engineering) research. During his neurosurgical training at Leeds (FRCS (SN) in 2013), he undertook further basic science research (funded by CRUK) and was awarded a PhD based on Glioma Modelling using induced Pluripotent Stem Cells (iPSCs) and Cerebral Organoids. He has spent time as a Visiting Research Collaborator at the Brain Tumour Research Centre at Sickkids in Toronto.
His clinical practice covers the full spectrum of general neurosurgery with a subspecialty interest in brain tumours; in particular gliomas, meningiomas and awake surgery. His basic science research interests focus on developing advanced in vitro and in vivo brain tumour models, studying residual glioma cell populations that are resistant to therapy and fuel recurrence, and developing local therapeutic treatments. He also leads a research portfolio in surgical technologies and devices which encompasses virtual/mixed reality, machine learning for early brain tumour diagnosis and malignant transformation, real-time intra-operative tumour visualisation and histology, in silico trials, and early phase neoadjuvant and repurposing trials. He is the Neurosurgery Lead for the NIHR Surgical MIC, Surgical Technologies Academy Incubator and RCS Leeds Institute of Clinical Trials Research. He is a member of the Academic Committee of the SBNS, BNOS Research Subcommittee and a HoloMedicine Association Founding Member. He peer-reviews for a number of journals and grant award committees, has published a number of papers and has obtained > £5M in grant funding.