Barrow Neurological Institute
Phoenix, United States
I am currently serving as an Associated Professor in the Department of Translational Neuroscience and a director of the Biostatistics Program, Ivy Brain Tumor Center at Barrow Neurological Institute. As a cancer biostatistician as well as a population health scientist over last twenty years, I have developed statistical methodologies and applications on pre-clinical and clinical trials (early phases) and observational studies as translational and clinical research with inter- and multi-disciplinary research teams. My current research interests include methodological development in clinical trials (Phase 0 trials) and data-driven observational studies with large haelth database. First, I have performed preclinical and Phase 0 trials of brain tumor studies on drug treatments studies for newly-diagnosed and recurrent patients in glioblastoma, meningioma, and other CNS cancers. I am focusing on developing a novel design approach utilizing Phase 0 trigger trials to maximize the success in Phase 3 neuro-oncology trials and evaluating of Phase 0 paradigm in brain tumor studies. Second, I have been developing quantitative methods using Mendelian randomization and instrumental methods to perform causal inference between chronic diseases and modifiable exposures in aneurysmal subarachnoid hemorrhage (aSAH) and Amyotrophic Lateral Sclerosis (ALS). Third, I have been developing genotype risk score methods to improve the ability to predict the risk of disease in a clinically relevant way.