Hormel Institute, University of Minnesota
Austin, United States
Lukmanul Hakkim Faruck, PhD. Researcher 5, Hormel Institute, University of Minnesota
My research focuses on understanding the role of histone post translational modifications (HPTM) in gliomagenesis. Mutations in Histone H3.3 variant H3F3A (K27M, G34R/V) occur in ~50% of pediatric high-grade gliomas which alters HPTM (lysine methylation and serine phosphorylation). This epigenetic dysregulation causes chromosome instability (CIN) and defective p53 check point which leads to aneuploidy. We adopt CRISPR cas9 approach (in vitro) and RCAS/TVA live retroviral gene transfer system (in vivo) to delineate the molecular mechanism of CIN in glioma and identify therapeutic targets.