Mayo Clinic Florida
Jacksonville, United States
I am an Associate Consultant and Assistant Professor of Neurosurgery, Neuroscience and Cancer Biology at Mayo Clinic Jacksonville. I obtained my PhD in Neuroscience at National Brain Research Center (Manesar, India), and then pursued post-doctoral training with Dr. Bruce Carter at Vanderbilt University Medical Center, where I studied the role of the p75 neurotrophin receptor in driving developmental cell death in sympathetic neurons and demonstrate that cleavage of this receptor is required for developmental cell death. During and subsequent to this time, I also pursued independent collaborations with Dr. William Kaelin and Dr. Susanne Schlisio at the Dana Farber Cancer Institute and Ludwig Cancer Institute on the tumor suppressor functions of the prolyl hydroxylase EglN3 and the kinesin KIF1Bβ. Through this period of training and independent research, I developed an abiding interest in the biology of malignant gliomas. For this reason, I joined H. Lee Moffitt Cancer Center to further my training in studying these tumors. At Moffitt, I developed extensive expertise in glioma model systems, including studies of oncolytic viral therapies in pre-clinical models of glioblastoma. I also applied my interest in neurotrophin receptor biology to glioblastoma. I joined Mayo Clinic Jacksonville in 2017 to continue translational research in glioblastoma. At Mayo Clinic, I study on molecular motors such as myosins, kinesins, transmembrane receptors and kinases in glioblastoma invasion, proliferation and treatment resistance. Essentially, they serve as convincing targets for the development of highly novel therapeutic approaches for treating glioblastoma. Overall, my research interests are to develop translational research program in glioblastoma.