Accelerating Drug Discovery Research using High-Content Screening Technology

High-Content Screening (HCS) is an image cytometry–based method used to measure cellular and subcellular biologies amenable to screening in the drug discovery space. The automated nature of both imaging and quantitative analysis enables the throughput ability to measure multiple time points and pharmacological concentrations that are both time- and resource- prohibitive to accomplish using conventional, manual methods. This technical seminar will focus on best practices to accelerate drug discovery using HCS technology. Practical considerations will be reviewed, including statistical methods to help prioritize which markers are chosen from assay development before scaling to screening campaigns. We will also investigate new technological advancements that can further increase the throughput required for high-throughput screening considerations.