Senior Scientist Waters Corporation, Massachusetts, United States
Join Waters for an in-depth look at methods and workflows designed to automate routine analysis of therapeutic mAbs in high volume applications. Developing and manufacturing of therapeutic mAbs requires analysis of many different critical quality attributes (CQAs) such as Fc glycosylation, oxidation, C-terminal lysine clipping, glycation among others. High-volume applications like clone selection, process development and stability studies generate many samples to be analyzed. This creates a bottleneck which can slow down the development of new therapeutics and provides a need for more automated sample preparation and analysis. Key
Learning Objectives: -How to accelerate therapeutic mAbs workflows by automating analysis of critical quality attributes (CQAs) -How to use an automated method that provides a reproducible profile of N-glycans released from human chorionic gonadotrophin (hCG) -How to automate Protein A purification to be able to analyze CQAs of mAbs directly from complex samples such as harvested cell culture fluid
