New Modalities

Molecular glues

Session Chair & Speaker - No Funding(s)

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  Vladislav Zarayskiy, PhD

  Director of Automation and Screening
  Monte Rosa Therapeutics, Massachusetts, United States

Molecular glues are a type of molecules that induces proximity of two proteins that normally wouldn't interact. Known glue molecules achieve this by changing the surface of their target proteins ("neosubstrates"). The best known molecular glues are binding neosubstrates to E3 ligases, thus, causing protein degradation.

Presentations:

• 4:00 PM – 4:30 PM

  Methods in quantitative assessment of protein degradation
  

  Radosław P. Nowak, PhD – Dana-Farber Cancer Institute
• 4:30 PM – 5:00 PM

  Rational molecular glue discovery as new frontier in targeted protein degradation
  

  Jesse J. Chen, PhD – RA Capital Management
• 5:00 PM – 5:30 PM

  Toolbox to discover new molecular glue degraders
  

  Vladislav Zarayskiy, PhD – Monte Rosa Therapeutics