Genedata Screener: Accelerating Drug Discovery by Automating Analysis Of Information-Rich Assays in Mass Spectrometry, Mechanistic Analysis and High Content Screening

The ability to perform complex assays in high-throughput, earlier in the R&D pipeline, serves to accelerate the pace of drug discovery. Genedata Screener is an out-of-the box platform that streamlines, scales up and standardizes the analysis of screening data − automating everything from data import to result reporting. Biopharmaceutical companies around the world use Screener to increase efficiency, capitalize on innovative, information-rich assay formats in early discovery, and deliver significant increases in project speed and data quality.

Screener is purpose-built to analyze the most important in vitro assays used in hit discovery, validation, and characterization. In our tutorial, we will highlight just three types of data that can be analyzed in Screener, including mass spectrometry, mechanistic analysis, and high content screening data.

Mass Spectrometry: first, we will demonstrate how Genedata Screener enables automated quality control and result calculation for high-throughput mass spectrometry screens. It integrates with multiple HT-MS instruments to directly import either raw data or pre-analyzed peaks, and it increases data processing efficiency and result-sharing across scientific teams.

Mechanistic Analysis: We will also show how Genedata Screener’s Mechanistic Analysis (MAP) platform can increase the success of drug screening with early inclusion of assays providing mechanistic and kinetic information on drug-target engagement. With Screener’s MAP workflow, mechanistic assays performed at scale on automation platforms can be rapidly analyzed, enabling routine characterization of thousands of analytes. Genedata Screener enables unmatched throughput by automating the data modelling and decision-making process for time-dependent target-enzyme binding analysis.

High Content Screening: Finally, we will illustrate how Genedata Imagence revolutionizes image analysis and High Content Screening using cutting-edge AI and deep learning-based tools, enabling novel phenotype classification and unparalleled insights. Genedata Imagence effectively increases assay robustness, sensitivity, and time-savings through the automation of analysis of production-level screens.