PhD University Medical Center Utrecht, Utrecht, Netherlands
Cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) are both inherited respiratory tract disorders, caused by monogenic mutations that attenuate mucus clearance mediated by the airway epithelium. Using upper airway epithelial stem cells, we are able to recapitulate the complex mucociliary airway epithelial tissue from individuals with CF and PCD in both 2D and 3D culture models. Besides basic research, patient-derived airway cultures can be applied as model for novel drug development and assessment of genotype-specific therapy efficacy. This will be further discussed during the presentation.
