Automation High-throughput Experimentation for Acceleration of Formulation Development

Automation High-throughput Experimentation for Acceleration of Formulation Development

Sharon Matamoros, Amanda Dingley, Matthew Bahr, Austin Phillip, Kris Angamuthu,
GlaxoSmithKline, 1250 South Collegeville Rd., Collegeville, PA 19426

The implementation of laboratory automation can accelerate the chemistry, manufacturing,

and control activities and build quality into the process. Our goal is to accelerate product development by designing, implementing and validating automation protocols that enable high throughput experiments focusing on the characterization of GSK therapeutics. Our automation capabilities include multi-functional Unchained Labs robotic platforms, Mettler Toledo Quantos & Chemspeed solid dispensing platforms, and Hamilton & Andrew liquid dispensing platforms. This poster describes our formulation development workflow to perform complex pre-formulation experiments with a limited amount of active pharmaceutical ingredient (API).  More than five vehicles in different concentrations of excipients, two time points and replicates were studied to understand the solubility of a long acting injectable (LAI). The results from this complex experiment inform decisions for developing a DoE to further interrogate the appropriate concentrations of excipients to produce the final clinical formulation.