Application Scientist Molecular Devices, LLC San Jose, CA, United States
Abstract: Assessing the generation of thrombin in a plasma sample allows one to better understand coagulation mechanisms. To meet the needs of researchers to determine the time-dependent changes in thrombin concentrations on a flexible platform, Technoclone has developed a plate reader-compatible kinetic assay format, the TECHNOTHROMBIN® TGA kit, using a fluorogenic substrate. Cleavage of the substrate occurs upon activation of the coagulation cascade by different concentrations of tissue factor and negatively charged phospholipids in plasma. Researchers can choose from a range of three triggers with the kit to study different areas of coagulation mechanisms. These areas include thrombophilia, haemophilia, anticoagulation, thrombogenity of microparticles, and drug development studies. All three triggers were tested on the SpectraMax® i3x Multi-Mode Microplate Reader with excellent results. After generating the data in SoftMax Pro® Software the data were transferred to Technoclone’s TECHNOTHROMBIN TGA evaluation file to calculate all thrombin generation parameters based on the thrombin generation curve. This poster demonstrates that the combination of the SpectraMax i3x reader and TECHNOTHROMBIN TGA kit offers an ideal platform to perform thrombin generation assays with good precision for research use.
Scan and Win! Complete as many scavenger hunt questions as possible. You will find scavenger hunt QR Codes to scan on participating posters. Each participating poster in the exhibit hall will have a QR code next to it. For virtual participants, look for the scavenger hunt icon for participating posters.
SLAS Events
Instructions
Each poster participating in the scavenger hunt will have a SCAVENGER HUNT QR code. When that QR code is scanned using the SLAS2022 app, question about the poster will appear. You must answer the question correctly to collect points. BE SURE TO EXPLORE THE POSTER BEFORE SCANNING THE CODE! SLAS will award three prizes to the participants with the most points.
1st Prize - Comp Reg + Hotel/Airfare to SLAS2023 in San Diego
2nd Prize - $50 Starbucks Gift Card
3Rd Prize - $25 AMEX Gift Card
Keep an eye on the leader boards to see who’s at the TOP. Winners will be announced after SLAS2022.
Each participating poster in the exhibit hall will have a QR code next to it. For virtual participants, look for the scavenger hunt icon for participating posters.
