High-throughput biological annotation of chemical space with the NCATS ASPIRE Initiative

Primary Author - December Poster(s)

JD

Jameson L. Dahlin, MD, PhD

Preclinical medicine and high-throughput biology consultant
NCATS
Damascus, MD, United States

Abstract:

This presentation will describe the high-throughput biology efforts in the National Center for Advancing Translational Sciences (NCATS) A Specialized Platform for Innovative Research Exploration (ASPIRE) Initiative. The ASPIRE biology team will support on-demand, project-specific biological assays and will also support a set of high-yield “core” assays for routine biological characterization of chemical matter produced from an integrated automated synthesis and AI/ML platform. Leveraging the extensive experience of NCATS in high-throughput screening, core philosophies of ASPIRE biology include reproducibility, adaptability, efficiency, sustainability, and usability. Examples of pilot programs will be presented, including the use of autonomous intelligent vehicles for sample ferrying, autonomous biological assay optimization, and high-content imaging assays to generate mechanism-of-action hypotheses.

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Each participating poster in the exhibit hall will have a QR code next to it. For virtual participants, look for the scavenger hunt icon for participating posters.