Advanced Instruments

Advanced Instruments is a global company offering a novel portfolio of analytical tools including, OsmoTECH®, a robust line of micro-osmometers to support bioprocessing and quality control (QC), and Solentim, a portfolio of best in class imaging and single-cell deposition technologies for cell line development workflows and assurance of clonality for regulatory bodies.

Osmolality is a critical parameter and delivers significant information across the bioprocessing workflow, from initiation of the culture system to the final product. Built specifically for the biotech industry, our osmometers seamlessly integrate into both your non-regulated and regulated GMP workflows ensuring increased yield, quality, and purity at every stage.

The latest addition to the OsmoTECH portfolio, the OsmoTECH HT, is the only plate-based micro-osmometer currently available to support the growing automation and high throughput needs in bioprocessing. The plate-based technology allows for seamless integration into process development and optimization workflows. Designed in a 96 well format this automation-friendly instrument ensures efficiency and acceleration of osmolality testing in cell line development, clone screening, early process, and formulation development. The OsmoTECH HT provides intuitive workflows and delivers unsurpassed data management and connectivity with 21 CFR compliance features for GMP workflows. 

Our Solentim portfolio enables the clonal isolation, outgrowth, and characterization of the highest value cells for monoclonal antibody upstream development and cell and gene therapy. This enables our customers to use these clones and have the documentation they were clonally-derived to confidently form their Master Cell Banks.

Solentim’s vision is to create an ecosystem offering scientists performing clonal selection with consistency across the workflow leading to reduced analysis time from days to minutes and the highest confidence in the selection of highest performing clones in preparation for scale-down mini bioreactor assessments. This will result from incorporating our VIPSTM single cell seeder, Cell Metric® whole well imager, the ICONTM titer, and cell productivity analyzer into the 21 CFR part 11 compliant STUDIUSTM data management platform.