(CS-082) Early Utilization of a Poly-lactic Acid Matrix for Treatment of Highly Complex Wounds

Co-Author(s):

Introduction: Traditional care of complex wounds has led to delays in healing and infection.1 Current wound care technologies have either been very similar or have similarly approached the wound healing cascade.^1-3 There has been many cellular tissue products introduced into wound care throughout the years.³ This has led to little innovation or change in how healing chronic wounds were approached. Literature suggests that poly-lactic acid may stimulate the healing process by supporting angiogenesis and the re-building of dermis. ^3-6 This study utilized a new poly-lactic acid matrix (PLAM) that supports wound healing at all levels of the wound healing cascade.

Methods: A synthetic PLAM guided wound wound closure system built as a bimodal foam membrane structure was used on patients with highly complex wounds. Pathology included Diabetic, Venous, and Surgical wounds. All wounds were conservitively treated for four weeks without significant healing. Weekly visits of wounds included debridement in office or surgical followed by placement of the PLAM affixed with a silicone non-adherent layer with appropriate outer dressings for fluid management. The patients were monitored weekly for reduction in wound size.

Results: Wounds progressed from fibrotic necrotic to granular to epithelialization with the utilization of the PLAM introduced earlier in the wound healing pathway. In addition, the increased healing fostered an enhanced quality of life and an increase in overall in patient satisfaction.

Discussion: The use of the PLAM earlier in the wound healing pathway allowed for faster conversion of the wound bed and full epithelialization. Enhancement of quality of life and satisfaction for patients  with highly complex wounds was noted in the study. The wound closure system built as a bimodal foam membrane structure allows for the healing of complex non-healing wounds. The products unique approach of the lactate molecule orchestration for events to support dermal proliferation within a supportive matrix was noted in the healing results. Further study is recommended to support the evolution of evidence and additional exploration for wound healing.

Trademarked Items:

References: 1. Chan, B., Cadarette, S,Wodchis, E., et al. Cost of illness studies in chronic ulcers: A systemic review. Journal of Wound Care, 2017. April1;26(sup4): S4-14.
2. Chen, KK., Elbuluk, AM., Vigorchik, JM., et al. The eddect of wound dressings on infection following total jointarthroplasty. Arthroplasty Today. 2018; 4:125-129.
3. Demidova, O., Manushin, S. Alloplastic skin substitute (Suprathel) dressings in treatment of donor sites in children with burns. Moressier 2019. https://www.mprressier.com/article/alloplastic-skin-substitute-dressings-treatment-donor-sites-children-burns/594bbebfd462b8028d893e61
4. Glat, P., Orgill, DP., Galiano, R, et al. Placental membrane provides improved healing efficacy and lower cost versus a tissue engineered human skin in the treatment of Diabetic Foot Ulcerations. Plastic Reconstruction Surgery Global Open. 2019. Aug 30;7(8):e2371.
5. Gurunluoglu, K., Demircan, M., Tascl, A., Uremis, MM., Turkoz, Y., Bag, HG, et al. The effects of two different burn dressings on serum oxidative stress indicators in children with partial burns. J Burn Care Res. 2019; 40(4):444050.
6. Wagner, S., et al. Stimulation of fibroblast proliferation by lactate mediated oxidants. Wound Repair Regen. 12 (2004), 368-373.