<b>Introduction</b>: A 55 year old male who had sustained a crush injury at work presented with a gangrenous surgical wound from an open forefoot amputation. The wound size was 11.0 x 13.0 x 1.0 (cm), i.e 143 cm<sup>3</sup>.<br/><br/><b>Methods</b>: The wound was debrided and the metatarsal heads were resected and 4 pieces of a 3x6 cm cellular umbilical tissue allograft were applied and sutured into the wound margins. Hyperbaric oxygen therapy was started and was continued for 86 treatments at 2.5 Atm. A shelf stable cellular amniotic membrane was then applied weekly for 13 weeks (as approved by the insurance). The allograft was covered with Mepitel as a secondary dressing and secured with Steristrips.<br /><br/><br/><b>Results</b>: In 4 weeks, after application of the umbilical allograft, the wound size decreased to 7.0 x 9.5 x 0.3 (cm), i.e 19.95 cm<sup>3</sup>, a decrease of 86%. <br />At the end of the 13 applications of the amniotic allograft, the wound had reduced to 0.4 x0.5 x0.1 (cm), i.e 0.02 cm<sup>3</sup>, which was a 99.99% decrease in volume than the initial presentation. At the last visit, 2 weeks post, the wound was completely healed.<br/><br/><b>Discussion</b>: This case presents an example of using two different types of cellular allografts in conjunction with hyperbaric oxygen therapy to salvage a limb and successfully achieve wound closure.<br/><br/><b>Trademarked Items</b>: <br/><br/><b>References</b>: <br/><br/>
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