Case Series/Study

(CS-085) The essential role that the ECM plays in healing Chronic Wounds A Piscine Acellular Matrix Xenograft (PDAM) A case series*

Co-Author(s):

Introduction: The extracellular matrix is not just an inert scaffold but acts as a biologic modulator. It plays an essential role in healing chronic wounds by modulating numerous cellular processes including cell proliferation, differentiation, and migration. It promotes cell regrowth, epithelization, and angiogenesis. It has anti-inflammatory and anti-infective effects. These processes essential to healing are regulated through the paracrine effect by which multiple matrix proteins in the ECM communicate with the patients’ cells to promote tissue repair. It achieves this in part through its micro and macrostructure that allow for the in growth, organization, and adhesion of cells. By anchoring key cells via cell adhesion and its structural matrix it allows for the ingrowth, communication and organization of these cells on a lattice that is the provides the basis of tissue repair.

Methods: A Piscine Acellular Matrix Xenograft (PDAM) * has been shown to promote healing in DFU, VLU and surgical wounds. A representative case series is presented.

Results:

Complete re-epithelization was achieved in _ of the _ ulcers. A healing rate of _percent was achieved with a closure time of _ weeks. Patients received an average of _grafts, a range of _ to _.

Discussion: Tissue engineered products are classified as either biologic dressing or biologic modulators (that influence the biologic process). This poster board presents a case series in which a cellular tissue product (CTP) namely A Piscine Acellular Matrix Xenograft (PDAM)* that due to its Macro and microstructure along with the macro molecules present have shown to be effective in healing DFU, VLU and surgical wounds. The biologic and material properties of this fish skin graft act as an effective and efficient ECM are reviewed and supported with a representative case series.

ECM has been shown to be a biologic modulator that through its paracrine effect, promotes healing on the cellular level. Through its anti-infective, anti-inflammatory modulation it expedites healing by reducing the inflammatory stage of healing that is prolonged in a chronic wound and it replaces the structural matrix that is degraded by MMPs present by a prolonged inflammatory phase.

Trademarked Items: *KerecisTM

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