(CS-050) Use of a Synthetic Hybrid-Scale Fiber Matrix* in the Treatment of Surgical Wounds

Complex wounds arise due to various etiologies and can require surgical intervention. These wounds can be difficult to heal and often require advanced therapies [1]. Current therapies such as biologic skin substitutes are limited in their availability to treat these wounds due to the risk of inflammatory response and disease transmission [2]. A synthetic hybrid-scale fiber matrix*, with an architecture similar to native extracellular matrix, offers an alternative in the treatment of complex surgical wounds [2]. In this case study, 13 patients with a total of 15 wounds were treated with the synthetic hybrid-scale fiber matrix in the surgical setting.

Methods:

A retrospective study of 13 patients with a total of 15 complex surgical wounds treated with the synthetic hybrid scale fiber matrix was conducted. Wound healing progress was observed, and the synthetic hybrid-scale fiber matrix was reapplied as deemed appropriate by the physician.

Results:

The average patient age was 60 years old. Wound etiologies included venous leg ulcers, infections, Mohs surgery, trauma, calciphylaxis, and frostbite among others. Patients had many co-morbidities including cancer, obesity, hypertension, diabetes, and chronic kidney disease.  The average starting wound size was 115.4 cm². Five wounds achieved complete closure in 40 days, with one being successfully bridged to a split thickness skin graft after regranulation of the wound bed. The remaining 10 wounds decreased in size by an average of 50% in 51 days. The average number of synthetic hybrid-scale fiber matrix reapplications was 3.

Discussion:

Complex surgical wounds, particularly in patients with multiple co-morbidities, can be difficult to manage. In this present study, all wounds treated with the synthetic hybrid-scale fiber matrix achieved decrease in total wound size, and 5 wounds completely healed. While this is a retrospective study with a small sample size, this demonstrates the ability of the synthetic hybrid-scale fiber matrix to re-granulate and re-epithelialize difficult to treat wounds. 

Trademarked Items: Restrata* Acera Surgical, Inc., St. Louis, Missouri

References: 1. Ferreira MC, Tuma P Jr, Carvalho VF, Kamamoto F. Complex wounds. Clinics (Sao Paulo). 2006 Dec;61(6):571-8. doi: 10.1590/s1807-59322006000600014. PMID: 17187095.
2. Fernandez L, Shar A, Matthews M, Kim P, et al. Synthetic hybrid-scale fiber matrix in the trauma and acute care surgical practice. Wounds. 2021;33(9):237-244