Developing a Dual Prodrug for Triggered Antibiotic Activation

Limiting antibiotic use in medicine and agriculture is helpful in reducing the development of resistance, but there is also a need for new therapeutic approaches for the treatment of infections. Our research focuses on the development of triggerable antibiotic prodrugs that can be used to reduce unnecessary antibiotic exposure in people and animals. We have developed a dual prodrug requiring two different triggers found in the area of infection for activation. We hypothesize this dual prodrug will improve the specificity of release.