Graduate Student University of Michigan Ann Arbor, Michigan
B immunity has long been underestimated for anti-cancer immunotherapy because secreting antibodies has been recognized as the main function of B cells in the traditional cancer immunology concept. However, more and more voices have indicated that healthy body immune communities and their collaboration, especially the involving of B and CD4+ T cells, are critical for better PD-1 responses and better prognosis across many types of cancers comparing only activating CD8+ T immunity. Based on this hypothesis, we synthesized a viral mimicry nanovaccine to boost cooperated activation of tumor antigen specific B and CD4+ T Cells, achieved better anti-tumor efficacy than activating only CD8+ T cells.
Learning Objectives:
Upon completion, participant will be able to know the mechanism of cancer vaccine.
Upon completion, participant will be able to know the mechanism of cooperated activation of B and CD4+ T cells.
Upon completion, participant will be able to understand the importance of cooperated activation of B and CD4+ T cells for anti-cancer immunity.
