PhD Student Virginia Commonwealth University Richmond, Virginia
1. Importance of cGAS-STING pathway in cancer immunotherapy. 2. Current strategies for cGAS-STING activation. 3. Advantages of cGAS targeting using small DNA molecules. 4. Application of lipid-based nanoparticles for efficient DNA delivery in vivo. 5. Modulation of tumor microenvironment using DNA-based cGAS agonist.
Learning Objectives:
Upon completion, participant will be able to understand the current role of cGAS-STING activation in cancer immunotherapy.
Upon completion, participant will be able to discuss the challenges of developing cGAS/STING agonists.
Upon completion, participant will be able to understand the advantages of small DNA-based cGAS agonist.
Upon completion, participant will be able to discuss the future work of small DNA-based cGAS agonist.
