Session: Rapid Fire: Bridging The Cross-Functional Silos To Expedite Compound Progression Into The Clinic (BM)
Positively Charged Surface in LIGHT Trimers Fused with Fc, a Ligand for Lymphotoxin-b Receptor (LTbR) and HVEM, Caused a Non-specific Interaction with Cells Leading to Fast Systemic Clearance in Mice
Principal Senior Scientific Researcher Genentech, Inc. South San Francisco, California
Characterization of these ADME properties at early stage using various approaches is very valuable for the selection of molecules with appropriate PK for further development.
