Graduate Student Researcher Florida A&M University Tallahassee, Florida
Backing membranes affect adhesion characteristics of various adhesives used in transdermal patches. The purpose of the current study was to evaluate the effect of various backing membranes on adhesion properties of different adhesives. Several silicone adhesives (amine compatible and non-amine compatible) including BIO-PSA 4302 and BIO-PSA 4501 were coated on different backing membranes and glass slides with 5 mg/cm2, 10 mg/cm2 and 15 mg/cm2 dry coat weight. Our results showed that both amine and non-amine compatible silicone adhesives demonstrated significant (p < 0.001) difference in the adhesive force required after coating the adhesives on different backing membranes. Additionally, our results revealed that adhesive force varies depended on a) type of adhesive b) dry coat weight and c) type of backing membrane. This is the first study showing detailed correlation between different backing membranes, dry coat weight, adhesives and the adhesive force required to unbind the probe from the adhesive patch.
Learning Objectives:
Upon completion, participants will be able to learn the effect of different backing membranes on adhesion properties of amine compatible and non-amine compatible silicone adhesives.
Upon completion, participants will be able to learn the effect of different dry coat weights of adhesives (amine compatible and non-amine compatible silicones) on their adhesion properties on backing membranes.
Upon completion, participants will be able to learn the effect of rheological properties of different silicone adhesives on the adhesive force required to unbind them from adhesive patches.
