Important Role of UGTs in Drug Metabolism and Drug-Drug Interactions

Tuesday, October 18, 2022

3:30 PM – 4:30 PM ET

Location:360 Stage #2, Exhibit Hall A&B

Presented By

Partner Presentation Speaker(s)

Maciej Czerwinski, PhD

Director, Scientific Consulting
Sekisui XenoTech, LLC
Kansas City, Kansas

The importance of glucuronidation is illustrated by the abundance and broad tissue distribution of the enzymes, diversity of substrates and reactions catalyzed, and number of distinctive UGTs and their genetic polymorphisms.

Their importance will be presented from regulatory and safety perspectives, along with their characteristics, examples of major glucuronides, distinctive properties of acyl-glucuronides and their significance for drug-drug interactions, factors contributing to underprediction of UGTs’ in vivo contributions, and laboratory approaches for improving these predictions.

Learning Objectives:

The participant will learn about the significance of UGT-mediated metabolism in the drug development process.
The participant will learn about the consequences of the formation of acyl-glucuronides.
The participant will learn about underprediction of in vivo UGT-mediated metabolism and how to predict it more accurately in vitro.