Physiological Considerations Around Food Effects On Oral Drug Bioavailability

Food effects on oral drug bioavailability are one of the main challenges in oral biopharmaceutics. This presentation will give an overview on how the human gastrointestinal physiology changes after food intake and how this can have an impact on the in vivo performance of orally administered drug products. Special attention will be paid to the process of gastric emptying as well as to the dynamic changes of luminal fluid volumes and luminal pH values in fasted and fed state. Moreover, it will be highlighted how the transit of oral formulations through the different parts of the GI tract is affected by food intake and how motility affects drug release. In this presentation, data from various modern in vivo techniques such as magnetic resonance imaging (MRI) or telemetric capsules will be presented.