Discovery and Basic Research
Zhenzhen Dong, PhD (she/her/hers)
Associate Director
Adesis Inc.
Joseph Fox, PhD
Professor
University of Delaware
This seminar will discuss recent advances in development of the tetrazine ligation– the fastest known bioorthogonal reaction. Tetrazine ligation has been used broadly by the scientific community, and finds application across chemical biology, medicine, nuclear medicine, and material science. The talk will describe advances in photochemistry, flow chemistry, and cross-coupling chemistry that have enabled access to improved trans-cyclooctene and tetrazine reagents including a suite of tool molecules developed in collaboration between UD and Pfizer.The talk will also discuss the catalytic activation of bioorthogonal chemistry with light, or CABL, a new method for ‘turning on’ rapid bioorthogonal chemistry in vivo and in cellular context through the photocatalyzed oxidation of dihydrotetrazines to tetrazines. Applicatiions to protein photoactivation and drug delivery will be discussed.