(M1130-07-40) The Effects of 3D-Printing Polyhedron Mini-tablets and Their Drug Delivery Kinetic Models

Monday, October 17, 2022

11:30 AM – 12:30 PM ET

Presenting Author(s)

YK

Young-Jin KIm

Student
Chungbuk National University
Cheongju-si, Ch'ungch'ong-bukto, Republic of Korea

Main Author(s)

CP

Chun-Woong Park, Ph.D.

Chungbuk National University
Cheongju-si, Cholla-bukto, Republic of Korea

Purpose: The combining hot melt extrusion (HME) with 3D printing (3DP)-fused deposition modeling (FDM) technology has been focused on the personalized medicines as tailoring dosages based on drug shapes, sizes, and release characteristics. In particular, the 3DP mini-tablets have an advantage in controlling the dissolution profile as personalized in chiledren without curshing the tablet or opening the capsule.

Methods: The Eudragit^® RS PO, HPC and theophylline was mixed with the different weight ratios. After that, when making tablets using a 3DP (Pro 2 Dual, Raise3D) with filaments extruded by HME (Process 11, Thermofischer Scientific), mini-tablets were fabricated from 5 regular polyhedrons having the same volume. The in vitro release rate of theophylline was evaluated using USP dissolution test apparatus II.

Results: As a result, we found the optimal weight ratio of Eudragit^® RS PO, HPC and theophylline for the 3DP printable filament without being too brittle or too soft. In addition, as the ratio of Eudragit^® RS PO to HPC increased, the drug release rate decreased. In terms of the relationship between the release rate and the surface area of polyhedral mini-tablet, an inverse proportional graph was obtained that the drug release rate decreased as the surface area increased from tetrahedron to hexahedron, octahedron, dodecahedron, and icosahedron.

Conclusion: It was concluded that drug release could be controlled and predicted by changing the surface area following the tablet geometry. In addition, the weight ratio of Eudragit^® RS PO and HPC of the filament also affected the release of the drug.

Acknowledgments: This study was supported by the National Research Foundation of Korea grants provided by the Korean government (NRF-2021R1A2C4002746 and 2017R1A5A2015541). This study was also supported by the Regional Innovation Strategy (RIS) through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (MOE).